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Ingredient Guide

Berberine: Benefits And Cautions

September 12, 2026 · 4 min read

Berberine is popular in blood sugar supplements. The evidence is weaker than the buzz.

What it is

Berberine is a plant alkaloid found in barberry, goldenseal and Oregon grape.

What the NIH says

The NIH’s NCCIH says there is weak evidence that berberine might help with blood sugar control.

Side effects

Mild to moderate nausea, diarrhea, bloating and constipation are the most common.

Interactions

It can add to metformin and interact with medicines processed by liver enzymes. Ask your pharmacist.

Who should avoid it

Pregnant or nursing women and young children should not use it. Ask your doctor if you have liver or kidney disease.

General information only. This article is not medical advice. GlycoZen is a dietary supplement and does not treat or prevent diabetes. Talk to your doctor or pharmacist about your own medicines.
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